Induction of HIF-1α by HIV-1 Infection in CD4(+) T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

Chronic immune activation and inflammation are hallmarks of HIV-1 infection and a major cause of serious non-AIDS events in HIV-1-infected individuals on antiretroviral treatment (ART). Herein, we show that cytosolic double-stranded DNA (dsDNA) generated in infected CD4(+) T cells during the HIV-1 r...

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Detalles Bibliográficos
Autores principales: Duette, Gabriel, Pereyra Gerber, Pehuen, Rubione, Julia, Perez, Paula S., Landay, Alan L., Crowe, Suzanne M., Liao, Zhaohao, Witwer, Kenneth W., Holgado, María Pía, Salido, Jimena, Geffner, Jorge, Sued, Omar, Palmer, Clovis S., Ostrowski, Matias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134101/
https://www.ncbi.nlm.nih.gov/pubmed/30206166
http://dx.doi.org/10.1128/mBio.00757-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134101/
https://www.ncbi.nlm.nih.gov/pubmed/30206166
http://dx.doi.org/10.1128/mBio.00757-18

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