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BTK modulates p73 activity to induce apoptosis independently of p53

Bruton’s tyrosine kinase (BTK) is a key component of B cell receptor signalling. Because of this, BTK plays an important role in cell proliferation and survival in various B cell malignancies. However, in certain contexts, BTK can also have tumour suppressor functions. We have previously shown that...

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Detalles Bibliográficos
Autores principales: Rada, Miran, Barlev, Nickolai, Macip, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134113/
https://www.ncbi.nlm.nih.gov/pubmed/30245853
http://dx.doi.org/10.1038/s41420-018-0097-7