TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling

TNF is not only a major effector molecule of PAMP/DAMP-activated macrophages, but also regulates macrophage function and viability. We recently demonstrated that TNFR2 triggers necroptosis in macrophages with compromised caspase activity by two cooperating mechanisms: induction of endogenous TNF wit...

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Detalles Bibliográficos
Autores principales: Siegmund, Daniela, Ehrenschwender, Martin, Wajant, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134143/
https://www.ncbi.nlm.nih.gov/pubmed/30206205
http://dx.doi.org/10.1038/s41419-018-0973-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134143/
https://www.ncbi.nlm.nih.gov/pubmed/30206205
http://dx.doi.org/10.1038/s41419-018-0973-3

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