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Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons

BACKGROUND: Most neurodegenerative diseases associated with protein aggregation are hallmarked by activation of astrocytes. However, how astrocytes are activated or which signaling pathways in astrocytes contribute to pathogenesis is not clear. One long-standing question is whether the responses in...

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Detalles Bibliográficos
Autores principales: Li, Y. X., Sibon, O. C. M., Dijkers, P. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134576/
https://www.ncbi.nlm.nih.gov/pubmed/30205834
http://dx.doi.org/10.1186/s12974-018-1278-2