Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

Acute myeloid leukemia (AML) with an NPM1 mutation (NPMc+) has a distinct gene expression signature and displays molecular abnormalities similar to mixed lineage leukemia (MLL), including aberrant expression of the PBX3 and HOXA gene cluster. However, it is unclear if the aberrant expression of PBX3...

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Detalles Bibliográficos
Autores principales: Zhang, Wu, Zhao, Chen, Zhao, Junmei, Zhu, Yongmei, Weng, Xiangqin, Chen, Qiusheng, Sun, Huiping, Mi, Jian-Qing, Li, Junmin, Zhu, Jiang, Chen, Zhu, Pandolfi, Pier Paolo, Chen, Saijuan, Yan, Xiaojing, Xu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134928/
https://www.ncbi.nlm.nih.gov/pubmed/30214626
http://dx.doi.org/10.7150/thno.26900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134928/
https://www.ncbi.nlm.nih.gov/pubmed/30214626
http://dx.doi.org/10.7150/thno.26900

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