Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes

Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Most DS patients carry de novo variants in SCN1A, resulting in Na(v)1.1 haploinsufficiency. Because SCN1A is expressed in heart and in brain, we proposed...

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Detalles Bibliográficos
Autores principales: Frasier, Chad R., Zhang, Helen, Offord, James, Dang, Louis T., Auerbach, David S., Shi, Huilin, Chen, Chunling, Goldman, Alica M., Eckhardt, L. Lee, Bezzerides, Vassilios J., Parent, Jack M., Isom, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135724/
https://www.ncbi.nlm.nih.gov/pubmed/30146492
http://dx.doi.org/10.1016/j.stemcr.2018.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135724/
https://www.ncbi.nlm.nih.gov/pubmed/30146492
http://dx.doi.org/10.1016/j.stemcr.2018.07.012

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