Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancement of oligodendrocyte survival could restore functional my...

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Detalles Bibliográficos
Autores principales: Elitt, Matthew S., Shick, H. Elizabeth, Madhavan, Mayur, Allan, Kevin C., Clayton, Benjamin L.L., Weng, Chen, Miller, Tyler E., Factor, Daniel C., Barbar, Lilianne, Nawash, Baraa S., Nevin, Zachary S., Lager, Angela M., Li, Yan, Jin, Fulai, Adams, Drew J., Tesar, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135742/
https://www.ncbi.nlm.nih.gov/pubmed/30146490
http://dx.doi.org/10.1016/j.stemcr.2018.07.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135742/
https://www.ncbi.nlm.nih.gov/pubmed/30146490
http://dx.doi.org/10.1016/j.stemcr.2018.07.015

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