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Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D (2) receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling
BACKGROUND AND PURPOSE: Because biological systems behave as networks, multi‐biomarker approaches increasingly replace single biomarker approaches in drug development. To improve the mechanistic insights into CNS drug effects, a plasma neuroendocrine fingerprint was identified using multi‐biomarker...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135786/ https://www.ncbi.nlm.nih.gov/pubmed/30051461 http://dx.doi.org/10.1111/bph.14452 |