Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

Human antibody-secreting cells (ASC) in peripheral blood are found after vaccination or infection but rapidly apoptose unless they migrate to the bone marrow (BM). Yet, elements of the BM microenvironment required to sustain long-lived plasma cells (LLPC) remain elusive. Here, we identify BM factors...

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Detalles Bibliográficos
Autores principales: Nguyen, Doan C., Garimalla, Swetha, Xiao, Haopeng, Kyu, Shuya, Albizua, Igor, Galipeau, Jacques, Chiang, Kuang-Yueh, Waller, Edmund K., Wu, Ronghu, Gibson, Greg, Roberson, James, Lund, Frances E., Randall, Troy D., Sanz, Iñaki, Lee, F. Eun-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135805/
https://www.ncbi.nlm.nih.gov/pubmed/30209264
http://dx.doi.org/10.1038/s41467-018-05853-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135805/
https://www.ncbi.nlm.nih.gov/pubmed/30209264
http://dx.doi.org/10.1038/s41467-018-05853-7

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