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Improved fragment-based protein structure prediction by redesign of search heuristics
Difficulty in sampling large and complex conformational spaces remains a key limitation in fragment-based de novo prediction of protein structure. Our previous work has shown that even for small-to-medium-sized proteins, some current methods inadequately sample alternative structures. We have develo...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135816/ https://www.ncbi.nlm.nih.gov/pubmed/30209258 http://dx.doi.org/10.1038/s41598-018-31891-8 |