A microfluidic device for isolating intact chromosomes from single mammalian cells and probing their folding stability by controlling solution conditions

Chromatin folding shows spatio-temporal fluctuations in living undifferentiated cells, but fixed spatial heterogeneity in differentiated cells. However, little is known about variation in folding stability along the chromatin fibres during differentiation. In addition, effective methods to investiga...

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Detalles Bibliográficos
Autores principales: Takahashi, Tomohiro, Okeyo, Kennedy O., Ueda, Jun, Yamagata, Kazuo, Washizu, Masao, Oana, Hidehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135817/
https://www.ncbi.nlm.nih.gov/pubmed/30209290
http://dx.doi.org/10.1038/s41598-018-31975-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135817/
https://www.ncbi.nlm.nih.gov/pubmed/30209290
http://dx.doi.org/10.1038/s41598-018-31975-5

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