Cargando…

Stabilization of HIF-2α impacts pancreas growth

Hypoxia inducible factors (HIFs) are critical regulators of the response to oxygen deficiency by activating target genes involved in a variety of biological functions. HIFs have been implicated in the pathophysiology of numerous pathologies including cancer. Patients with mutations in the von Hippel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flores-Martínez, Alvaro, García-Núñez, Alejandro, Rojas, Anabel, Cano, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135861/ https://www.ncbi.nlm.nih.gov/pubmed/30209343 http://dx.doi.org/10.1038/s41598-018-32054-5

Ejemplares similares

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity
por: Muñoz-Bravo, Jose Luis, et al.
Publicado: (2016)

Elimination of Von Hippel-Lindau Function Perturbs Pancreas Endocrine Homeostasis in Mice
por: Puri, Sapna, et al.
Publicado: (2013)

Stabilization of HIF-1α and HIF-2α, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model
por: Malchenko, Sergey, et al.
Publicado: (2017)

Regulation of HIF-1α stability by lysine methylation
por: Baek, Sung Hee, et al.
Publicado: (2016)

HIF1α stabilization in hypoxia is not oxidant-initiated
por: Kumar, Amit, et al.
Publicado: (2021)

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
por: Mira, Emilia, et al.
Publicado: (2018)

Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α
por: Jian, Cheng-Bang, et al.
Publicado: (2022)

Real-Time Imaging of HIF-1α Stabilization and Degradation
por: Moroz, Ekaterina, et al.
Publicado: (2009)

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
por: Vukovic, Milica, et al.
Publicado: (2015)

Effects of HIF-1α and HIF2α on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts
por: Biswas, Swethajit, et al.
Publicado: (2010)

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability
por: Park, Mi Hee, et al.
Publicado: (2014)

The Wilms’ tumor suppressor gene regulates pancreas homeostasis and repair
por: Ariza, Laura, et al.
Publicado: (2019)

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy
por: Hu, Sunli, et al.
Publicado: (2020)

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
por: Smythies, James A, et al.
Publicado: (2018)

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α
por: Forristal, C E, et al.
Publicado: (2015)

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success
por: Branco-Price, Cristina, et al.
Publicado: (2012)

HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells
por: Arreola, Alexandra, et al.
Publicado: (2014)

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells
por: Moreno Roig, Eloy, et al.
Publicado: (2019)

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm
por: Schofield, Heather K., et al.
Publicado: (2017)

Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
por: Dey, Anindya, et al.
Publicado: (2020)

Targeting HIF-2α in the Tumor Microenvironment: Redefining the Role of HIF-2α for Solid Cancer Therapy
por: Davis, Leah, et al.
Publicado: (2022)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors
por: Lazzara, Francesca, et al.
Publicado: (2020)

HDAC8 Deacetylates HIF-1α and Enhances Its Protein Stability to Promote Tumor Growth and Migration in Melanoma
por: Kim, Ji Yoon, et al.
Publicado: (2023)

ASC modulates HIF-1α stability and induces cell mobility in OSCC
por: Wu, Chi-Sheng, et al.
Publicado: (2020)

Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
por: Amin, Firman Zulkifli, et al.
Publicado: (2018)

HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide
por: Feng, Nan, et al.
Publicado: (2016)

Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia
por: AQUINO-GÁLVEZ, ARNOLDO, et al.
Publicado: (2016)

Differential effects of HIF2α antagonist and HIF2α silencing in renal cancer and sensitivity to repurposed drugs
por: Arnaiz, Esther, et al.
Publicado: (2021)

Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization
por: Sun, Wenyue, et al.
Publicado: (2011)

Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells
por: Florczyk, Urszula, et al.
Publicado: (2011)

Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma
por: Liu, Yan-Mei, et al.
Publicado: (2016)

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice
por: Saini, Yogesh, et al.
Publicado: (2015)

LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium
por: Ju, Sujin, et al.
Publicado: (2021)

IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer
por: Shigeta, Keisuke, et al.
Publicado: (2023)

Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
por: Kondo, Keiichi, et al.
Publicado: (2003)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth
Publicado: (2003)

Simulation Predicts IGFBP2-HIF1α Interaction Drives Glioblastoma Growth
por: Lin, Ka Wai, et al.
Publicado: (2015)

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
por: Nakazawa, Michael S., et al.
Publicado: (2016)

Reduced HIF-1α Stability Induced by 6-Gingerol Inhibits Lung Cancer Growth through the Induction of Cell Death
por: Kim, Min Jeong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5m2qgbre3lls1id74jd1p3tbs5