A Large-Scale Gene Expression Intensity-Based Similarity Metric for Drug Repositioning

Biological systems often respond to a specific environmental or genetic perturbation without pervasive gene expression changes. Such robustness to perturbations, however, is not reflected on the current computational strategies that utilize gene expression similarity metrics for drug discovery and r...

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Detalles Bibliográficos
Autores principales: Huang, Chen-Tsung, Hsieh, Chiao-Hui, Oyang, Yen-Jen, Huang, Hsuan-Cheng, Juan, Hsueh-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135902/
https://www.ncbi.nlm.nih.gov/pubmed/30267685
http://dx.doi.org/10.1016/j.isci.2018.08.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135902/
https://www.ncbi.nlm.nih.gov/pubmed/30267685
http://dx.doi.org/10.1016/j.isci.2018.08.017

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