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A Large-Scale Gene Expression Intensity-Based Similarity Metric for Drug Repositioning
Biological systems often respond to a specific environmental or genetic perturbation without pervasive gene expression changes. Such robustness to perturbations, however, is not reflected on the current computational strategies that utilize gene expression similarity metrics for drug discovery and r...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135902/ https://www.ncbi.nlm.nih.gov/pubmed/30267685 http://dx.doi.org/10.1016/j.isci.2018.08.017 |