Rethinking non-inferiority: a practical trial design for optimising treatment duration

BACKGROUND: Trials to identify the minimal effective treatment duration are needed in different therapeutic areas, including bacterial infections, tuberculosis and hepatitis C. However, standard non-inferiority designs have several limitations, including arbitrariness of non-inferiority margins, cho...

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Detalles Bibliográficos
Autores principales: Quartagno, Matteo, Walker, A Sarah, Carpenter, James R, Phillips, Patrick PJ, Parmar, Mahesh KB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136078/
https://www.ncbi.nlm.nih.gov/pubmed/29871495
http://dx.doi.org/10.1177/1740774518778027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136078/
https://www.ncbi.nlm.nih.gov/pubmed/29871495
http://dx.doi.org/10.1177/1740774518778027

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