Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours

BACKGROUND: There are multiple copies of mitochondrial DNA (mtDNA) present in each cell type, and they are strictly regulated in a cell-specific manner by a group of nuclear-encoded mtDNA-specific replication factors. This strict regulation of mtDNA copy number is mediated by cell-specific DNA methy...

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Detalles Bibliográficos
Autores principales: Sun, Xin, St John, Justin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136172/
https://www.ncbi.nlm.nih.gov/pubmed/30208958
http://dx.doi.org/10.1186/s13072-018-0223-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136172/
https://www.ncbi.nlm.nih.gov/pubmed/30208958
http://dx.doi.org/10.1186/s13072-018-0223-z

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