Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds

An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics were converted into polycyclic scaffolds displaying...

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Detalles Bibliográficos
Autores principales: Moni, Lisa, De Moliner, Fabio, Garbarino, Silvia, Saupe, Jörn, Mang, Christian, Basso, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136273/
https://www.ncbi.nlm.nih.gov/pubmed/30238002
http://dx.doi.org/10.3389/fchem.2018.00369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136273/
https://www.ncbi.nlm.nih.gov/pubmed/30238002
http://dx.doi.org/10.3389/fchem.2018.00369

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