Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

A new class of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors based on disaccharide nucleosides was identified. TDP1 plays an essential role in the resistance of cancer cells to currently used antitumour drugs based on Top1 inhibitors such as topotecan and irinotecan. The most effective inhibitor...

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Detalles Bibliográficos
Autores principales: Komarova, Anastasia O., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Kulikova, Irina V., Oslovsky, Vladimir E., Zakharova, Olga D., Zakharenko, Alexandra L., Mikhailov, Sergey N., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136360/
https://www.ncbi.nlm.nih.gov/pubmed/30191738
http://dx.doi.org/10.1080/14756366.2018.1509210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136360/
https://www.ncbi.nlm.nih.gov/pubmed/30191738
http://dx.doi.org/10.1080/14756366.2018.1509210

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