Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Excessive manganese (Mn) can accumulate in the striatum of the brain following overexposure. Oxidative stress is a well-recognized mechanism in Mn-induced neurotoxicity. It has been proven that glutathione (GSH) depletion is a key factor in oxidative damage during Mn exposure. However, no study has...

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Detalles Bibliográficos
Autores principales: Yang, Xinxin, Yang, Haibo, Wu, Fengdi, Qi, Zhipeng, Li, Jiashuo, Xu, Bin, Liu, Wei, Xu, Zhaofa, Deng, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136513/
https://www.ncbi.nlm.nih.gov/pubmed/30228854
http://dx.doi.org/10.1155/2018/4235695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136513/
https://www.ncbi.nlm.nih.gov/pubmed/30228854
http://dx.doi.org/10.1155/2018/4235695

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