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Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index
In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of different chemical nature, were compressed at differen...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136784/ https://www.ncbi.nlm.nih.gov/pubmed/30212557 http://dx.doi.org/10.1371/journal.pone.0203846 |
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author | Nofrerias, Isaac Nardi, Anna Suñé-Pou, Marc Boeckmans, Joost Suñé-Negre, Josep Maria García-Montoya, Encarna Pérez-Lozano, Pilar Ticó-Grau, Josep Ramón Miñarro-Carmona, Montserrat |
author_facet | Nofrerias, Isaac Nardi, Anna Suñé-Pou, Marc Boeckmans, Joost Suñé-Negre, Josep Maria García-Montoya, Encarna Pérez-Lozano, Pilar Ticó-Grau, Josep Ramón Miñarro-Carmona, Montserrat |
author_sort | Nofrerias, Isaac |
collection | PubMed |
description | In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of different chemical nature, were compressed at different heights. Their compression and their tablet characterization enable establishing a powder weight for compression in accordance with its bulk density. Therefore, the resulting tablet will have a height within a defined range of heights where it has no critical effects on its hardness. Then, the impact of this optimization is shown in a formula development, one of the main SeDeM’s applications. A mathematical equation was used to calculate the theoretical amount of excipient to formulate the API according to both methodologies. The compression results demonstrate that the characterization with the NM-Icd is more accurate than the previous one while preserving its simplicity. |
format | Online Article Text |
id | pubmed-6136784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-61367842018-09-27 Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index Nofrerias, Isaac Nardi, Anna Suñé-Pou, Marc Boeckmans, Joost Suñé-Negre, Josep Maria García-Montoya, Encarna Pérez-Lozano, Pilar Ticó-Grau, Josep Ramón Miñarro-Carmona, Montserrat PLoS One Research Article In this study, we suggest optimizing the methodology to determine the Cohesion Index (Icd) in order to avoid mistaken characterizations due to powder bulk density. For this purpose, five different excipients, with different bulk densities and of different chemical nature, were compressed at different heights. Their compression and their tablet characterization enable establishing a powder weight for compression in accordance with its bulk density. Therefore, the resulting tablet will have a height within a defined range of heights where it has no critical effects on its hardness. Then, the impact of this optimization is shown in a formula development, one of the main SeDeM’s applications. A mathematical equation was used to calculate the theoretical amount of excipient to formulate the API according to both methodologies. The compression results demonstrate that the characterization with the NM-Icd is more accurate than the previous one while preserving its simplicity. Public Library of Science 2018-09-13 /pmc/articles/PMC6136784/ /pubmed/30212557 http://dx.doi.org/10.1371/journal.pone.0203846 Text en © 2018 Nofrerias et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nofrerias, Isaac Nardi, Anna Suñé-Pou, Marc Boeckmans, Joost Suñé-Negre, Josep Maria García-Montoya, Encarna Pérez-Lozano, Pilar Ticó-Grau, Josep Ramón Miñarro-Carmona, Montserrat Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index |
title | Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index |
title_full | Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index |
title_fullStr | Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index |
title_full_unstemmed | Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index |
title_short | Optimization of the Cohesion Index in the SeDeM Diagram Expert System and application of SeDeM Diagram: An improved methodology to determine the Cohesion Index |
title_sort | optimization of the cohesion index in the sedem diagram expert system and application of sedem diagram: an improved methodology to determine the cohesion index |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136784/ https://www.ncbi.nlm.nih.gov/pubmed/30212557 http://dx.doi.org/10.1371/journal.pone.0203846 |
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