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Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies

Immune checkpoint blockade is less efficient in patients bearing immunologically ‘cold’ tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies publis...

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Detalles Bibliográficos
Autores principales: Gujar, Shashi, Pol, Jonathan G., Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136862/
https://www.ncbi.nlm.nih.gov/pubmed/30221036
http://dx.doi.org/10.1080/2162402X.2018.1442169