Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies

Immune checkpoint blockade is less efficient in patients bearing immunologically ‘cold’ tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies publis...

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Detalles Bibliográficos
Autores principales: Gujar, Shashi, Pol, Jonathan G., Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136862/
https://www.ncbi.nlm.nih.gov/pubmed/30221036
http://dx.doi.org/10.1080/2162402X.2018.1442169
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author Gujar, Shashi
Pol, Jonathan G.
Kroemer, Guido
author_facet Gujar, Shashi
Pol, Jonathan G.
Kroemer, Guido
author_sort Gujar, Shashi
collection PubMed
description Immune checkpoint blockade is less efficient in patients bearing immunologically ‘cold’ tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies published in Science Translational Medicine show that adjuvant-like activities of oncolytic viruses make brain and breast tumors ‘hot’ and sensitize them for subsequent immune checkpoint blockade.
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spelling pubmed-61368622018-09-14 Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies Gujar, Shashi Pol, Jonathan G. Kroemer, Guido Oncoimmunology Editorial Immune checkpoint blockade is less efficient in patients bearing immunologically ‘cold’ tumors. Oncolytic viruses, which were originally discovered for their ability to preferentially kill malignant cells, can recondition the tumor microenvironment. Supporting this hypothesis, two new studies published in Science Translational Medicine show that adjuvant-like activities of oncolytic viruses make brain and breast tumors ‘hot’ and sensitize them for subsequent immune checkpoint blockade. Taylor & Francis 2018-03-13 /pmc/articles/PMC6136862/ /pubmed/30221036 http://dx.doi.org/10.1080/2162402X.2018.1442169 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Editorial
Gujar, Shashi
Pol, Jonathan G.
Kroemer, Guido
Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
title Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
title_full Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
title_fullStr Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
title_full_unstemmed Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
title_short Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
title_sort heating it up: oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136862/
https://www.ncbi.nlm.nih.gov/pubmed/30221036
http://dx.doi.org/10.1080/2162402X.2018.1442169
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