Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition a...

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Detalles Bibliográficos
Autores principales: Noman, Muhammad Zaeem, Paggetti, Jerome, Moussay, Etienne, Berchem, Guy, Janji, Bassam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136884/
https://www.ncbi.nlm.nih.gov/pubmed/30221048
http://dx.doi.org/10.1080/2162402X.2018.1452583
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author Noman, Muhammad Zaeem
Paggetti, Jerome
Moussay, Etienne
Berchem, Guy
Janji, Bassam
author_facet Noman, Muhammad Zaeem
Paggetti, Jerome
Moussay, Etienne
Berchem, Guy
Janji, Bassam
author_sort Noman, Muhammad Zaeem
collection PubMed
description Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition as a cutting-edge approach to fully exploit the anti-tumor properties of NK cells in a wide variety of cancer patients.
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spelling pubmed-61368842018-09-14 Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target Noman, Muhammad Zaeem Paggetti, Jerome Moussay, Etienne Berchem, Guy Janji, Bassam Oncoimmunology Author's View Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition as a cutting-edge approach to fully exploit the anti-tumor properties of NK cells in a wide variety of cancer patients. Taylor & Francis 2018-04-25 /pmc/articles/PMC6136884/ /pubmed/30221048 http://dx.doi.org/10.1080/2162402X.2018.1452583 Text en © 2018 The Author(s). Published with Taylor & Francis Group. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's View
Noman, Muhammad Zaeem
Paggetti, Jerome
Moussay, Etienne
Berchem, Guy
Janji, Bassam
Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
title Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
title_full Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
title_fullStr Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
title_full_unstemmed Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
title_short Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target
title_sort driving natural killer cells toward the melanoma tumor battlefield: autophagy as a valuable therapeutic target
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136884/
https://www.ncbi.nlm.nih.gov/pubmed/30221048
http://dx.doi.org/10.1080/2162402X.2018.1452583
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