YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells

T cells infiltrate affected organs in chronic infections and malignancy, but they may fail to eradicate virus-infected cells or tumor because of exhaustion. This report describes a Yin Yang-1 (YY1)-centered mechanism for diverse components that have been correlated with exhaustion. Utilizing an in v...

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Detalles Bibliográficos
Autores principales: Balkhi, Mumtaz Y., Wittmann, Gabor, Xiong, Fang, Junghans, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136936/
https://www.ncbi.nlm.nih.gov/pubmed/30428369
http://dx.doi.org/10.1016/j.isci.2018.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136936/
https://www.ncbi.nlm.nih.gov/pubmed/30428369
http://dx.doi.org/10.1016/j.isci.2018.03.009

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