Development of an antibody fragment that stabilizes GPCR/G-protein complexes

Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular complexes. Despite this progress, the application of high-resolution cryo-EM to G protein coupled receptors (GPCRs) in complex with heterotrimeric G p...

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Detalles Bibliográficos
Autores principales: Maeda, Shoji, Koehl, Antoine, Matile, Hugues, Hu, Hongli, Hilger, Daniel, Schertler, Gebhard F. X., Manglik, Aashish, Skiniotis, Georgios, Dawson, Roger J. P., Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137068/
https://www.ncbi.nlm.nih.gov/pubmed/30213947
http://dx.doi.org/10.1038/s41467-018-06002-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137068/
https://www.ncbi.nlm.nih.gov/pubmed/30213947
http://dx.doi.org/10.1038/s41467-018-06002-w

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