High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation

Conjugation of small molecule agonists of Toll-like receptor 7 (TLR7) to proteins, lipids, or polymers is known to modulate potency, and the physical form or formulation of these conjugates is likely to have a major effect on their immunostimulatory activity. Here, we studied the effect of formulati...

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Detalles Bibliográficos
Autores principales: Gadd, Adam J.R., Castelletto, Valeria, Kabova, Elena, Shankland, Kenneth, Perrie, Yvonne, Hamley, Ian, Cobb, Alexander J.A., Greco, F., Edwards, Alexander D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137072/
https://www.ncbi.nlm.nih.gov/pubmed/30048801
http://dx.doi.org/10.1016/j.ejps.2018.07.048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137072/
https://www.ncbi.nlm.nih.gov/pubmed/30048801
http://dx.doi.org/10.1016/j.ejps.2018.07.048

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