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High potency of lipid conjugated TLR7 agonist requires nanoparticulate or liposomal formulation
Conjugation of small molecule agonists of Toll-like receptor 7 (TLR7) to proteins, lipids, or polymers is known to modulate potency, and the physical form or formulation of these conjugates is likely to have a major effect on their immunostimulatory activity. Here, we studied the effect of formulati...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137072/ https://www.ncbi.nlm.nih.gov/pubmed/30048801 http://dx.doi.org/10.1016/j.ejps.2018.07.048 |