Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression

G protein-coupled receptor 56 (GPR56) is highly expressed in acute myeloid leukemia (AML) cells with high EVI1 expression (EVI1(high) AML). Because GPR56 is a transcriptional target of EVI1 and silencing of GPR56 expression induces apoptosis, we developed a novel drug to suppress GPR56 expression in...

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Detalles Bibliográficos
Autores principales: Saha, Hasi Rani, Kaneda-Nakashima, Kazuko, Shimosaki, Shunsuke, Suekane, Akira, Sarkar, Bidhan, Saito, Yusuke, Ogoh, Honami, Nakahata, Shingo, Inoue, Kentaro, Watanabe, Takayoshi, Nagase, Hiroki, Morishita, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137133/
https://www.ncbi.nlm.nih.gov/pubmed/30214063
http://dx.doi.org/10.1038/s41598-018-32205-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137133/
https://www.ncbi.nlm.nih.gov/pubmed/30214063
http://dx.doi.org/10.1038/s41598-018-32205-8

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