Cargando…

METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice

Physical activity has many beneficial effects on metabolic disorders, such as obesity, insulin resistance, and diabetes. Meteorin-like protein (METRNL), a novel secreted protein homologous to the neurotrophin Metrn, is induced after exercise in the skeletal muscle. Herein, we investigated the effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Tae Woo, Lee, Sung Hoon, Kim, Hyoung-Chun, Bang, Joon Seok, Abd El-Aty, A. M., Hacımüftüoğlu, Ahmet, Shin, Yong Kyoo, Jeong, Ji Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137187/ https://www.ncbi.nlm.nih.gov/pubmed/30213948 http://dx.doi.org/10.1038/s12276-018-0147-5

Ejemplares similares

Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice
por: Jung, Tae Woo, et al.
Publicado: (2017)

The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance
por: Aguilar-Recarte, David, et al.
Publicado: (2021)

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
por: Lee, Jung Ok, et al.
Publicado: (2020)

Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis
por: Zheng, Sili, et al.
Publicado: (2023)

PPARδ Attenuates Alcohol-Mediated Insulin Resistance by Enhancing Fatty Acid-Induced Mitochondrial Uncoupling and Antioxidant Defense in Skeletal Muscle
por: Koh, Jin-Ho, et al.
Publicado: (2020)

Clinically confirmed DEL-1 as a myokine attenuates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes via AMPK/HO-1- pathway
por: Kwon, Chang Hyuk, et al.
Publicado: (2020)

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
por: Zhou, Yuxia, et al.
Publicado: (2023)

Serum Metrnl Level is Correlated with Insulin Resistance, But Not with β-Cell Function in Type 2 Diabetics
por: Wang, Chuan, et al.
Publicado: (2019)

Metrnl: a secreted protein with new emerging functions
por: Zheng, Si-li, et al.
Publicado: (2016)

Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR-δ/AMPK pathway
por: Feng, Xiaoli, et al.
Publicado: (2011)

Ginsenoside Rb3 ameliorates podocyte injury under hyperlipidemic conditions via PPARδ- or SIRT6-mediated suppression of inflammation and oxidative stress
por: Oh, Heeseung, et al.
Publicado: (2023)

MicroRNA-29a induces insulin resistance by targeting PPARδ in skeletal muscle cells
por: ZHOU, YUEHUA, et al.
Publicado: (2016)

Serum Metrnl is associated with the presence and severity of coronary artery disease
por: Liu, Zheng‐Xia, et al.
Publicado: (2018)

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion
por: Cohen, Guy, et al.
Publicado: (2011)

Combined pharmacological activation of AMPK and PPAR δ potentiates the effects of exercise in trained mice
por: Manio, Mark Christian C., et al.
Publicado: (2016)

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy
por: Lu, Qing-Bo, et al.
Publicado: (2022)

Decreased serum interleukin‐41/Metrnl levels in patients with Graves' disease
por: Gong, Luping, et al.
Publicado: (2022)

Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile
por: Ding, Xiaoyu, et al.
Publicado: (2022)

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration
por: Angione, Alison R, et al.
Publicado: (2011)

Aster glehni Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPARδ-AMPK Pathway
por: Lee, Yong-Jik, et al.
Publicado: (2018)

Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions
por: Han, Yoon-Mi, et al.
Publicado: (2020)

Meteorin-Like Protein (Metrnl) in Obesity, during Weight Loss and in Adipocyte Differentiation
por: Schmid, Andreas, et al.
Publicado: (2021)

Serum Levels of Meteorin-Like (Metrnl) Are Increased in Patients with Newly Diagnosed Type 2 Diabetes Mellitus and Are Associated with Insulin Resistance
por: Wang, Kexin, et al.
Publicado: (2019)

Meteorin-Like (METRNL) Attenuates Myocardial Ischemia/Reperfusion Injury-Induced Cardiomyocytes Apoptosis by Alleviating Endoplasmic Reticulum Stress via Activation of AMPK-PAK2 Signaling in H9C2 Cells
por: Xu, Ling, et al.
Publicado: (2020)

A Comprehensive Review of Pesticide Residues in Peppers
por: Shim, Jae-Han, et al.
Publicado: (2023)

An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle
por: Cho, Si Young, et al.
Publicado: (2012)

High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δ Agonism
por: Benetti, Elisa, et al.
Publicado: (2013)

Magnetic molecularly imprinted polymers for the detection of aminopyralid in milk using dispersive solid-phase extraction
por: He, Yahui, et al.
Publicado: (2019)

NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?
por: Mackenzie, Gerardo G., et al.
Publicado: (2008)

AMPK phosphorylates PPARδ to mediate its stabilization, inhibit glucose and glutamine uptake and colon tumor growth
por: Ding, Jiajun, et al.
Publicado: (2021)

PPAR-δ in Vascular Pathophysiology
por: Wang, Nanping
Publicado: (2008)

Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells
por: Zhang, Sai-long, et al.
Publicado: (2020)

Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle
por: Fan, Liyan, et al.
Publicado: (2022)

Developmental endothelial locus-1 attenuates palmitate-induced apoptosis in tenocytes through the AMPK/autophagy-mediated suppression of inflammation and endoplasmic reticulum stress
por: Park, Tae Jun, et al.
Publicado: (2022)

PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy
por: Chen, Miao, et al.
Publicado: (2021)

AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles
por: Jensen, Jørgen, et al.
Publicado: (2017)

Effects of Exercise Training on PPARβ/δ Expression in Skeletal Muscle of Rats with Spontaneous Hypertension
por: YANG, MINGXUAN, et al.
Publicado: (2022)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation
por: Tong, Lei, et al.
Publicado: (2019)

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo
por: Higgins, Larry G., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_rclsi8mfmfedhiag3in0tnn2sk