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Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics

Despite extensive research on the canonical Wnt signaling pathway, the mechanism by which this signal downregulates the activity of destruction complexes and inhibits β-catenin degradation remains controversial. In particular, recent attention has focused on two main competing mechanisms—inhibition...

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Detalles Bibliográficos
Autores principales: Mukherjee, Abhirup, Dhar, Neha, Stathos, Mark, Schaffer, David V., Kane, Ravi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137275/
https://www.ncbi.nlm.nih.gov/pubmed/30240607
http://dx.doi.org/10.1016/j.isci.2018.07.007