Cargando…

Lopinavir, an HIV-1 peptidase inhibitor, induces alteration on the lipid metabolism of Leishmania amazonensis promastigotes

The anti-leishmania effects of HIV peptidase inhibitors (PIs) have been widely reported; however, the biochemical target and mode of action are still a matter of controversy in Leishmania parasites. Considering the possibility that HIV-PIs induce lipid accumulation in Leishmania amazonensis, we anal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rebello, Karina M., Andrade-Neto, Valter V., Zuma, Aline A., Motta, Maria Cristina M., Gomes, Claudia Regina B., de Souza, Marcus Vinícius N., Atella, Geórgia C., Branquinha, Marta H., Santos, André L. S., Torres-Santos, Eduardo Caio, d'Avila-Levy, Claudia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2018
Materias:	Special Issue Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137378/ https://www.ncbi.nlm.nih.gov/pubmed/29806577 http://dx.doi.org/10.1017/S0031182018000823

Ejemplares similares

Miltefosine-Lopinavir Combination Therapy Against Leishmania infantum Infection: In vitro and in vivo Approaches
por: Rebello, Karina M., et al.
Publicado: (2019)

The Calpain Inhibitor MDL28170 Induces the Expression of Apoptotic Markers in Leishmania amazonensis Promastigotes
por: Marinho, Fernanda A., et al.
Publicado: (2014)

HIV Aspartyl Peptidase Inhibitors Interfere with Cellular Proliferation, Ultrastructure and Macrophage Infection of Leishmania amazonensis
por: Santos, Lívia O., et al.
Publicado: (2009)

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes
por: Balanco, José Mário F., et al.
Publicado: (2019)

Leishmania amazonensis Promastigotes or Extracellular Vesicles Modulate B-1 Cell Activation and Differentiation
por: Reis, Natasha Ferraz de Campos, et al.
Publicado: (2020)

Evaluation of Macroalgae Sulfated Polysaccharides on the Leishmania (L.) amazonensis Promastigote
por: Pires, Camila Lehnhardt, et al.
Publicado: (2013)

Detection and activity of MMP-2 and MMP-9 in Leishmania amazonensis and Leishmania braziliensis promastigotes
por: Costa, Brenda Furtado, et al.
Publicado: (2023)

Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis
por: Andrade-Neto, Valter Viana, et al.
Publicado: (2022)

Oral effectiveness of PMIC4, a novel hydroxyethylpiperazine analogue, in Leishmania amazonensis
por: Vasconcelos, Mariela Ferreira de, et al.
Publicado: (2014)

Leishmania amazonensis Promastigotes Present Two Distinct Modes of Nucleus and Kinetoplast Segregation during Cell Cycle
por: da Silva, Marcelo Santos, et al.
Publicado: (2013)

Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis
por: de Macedo-Silva, Sara Teixeira, et al.
Publicado: (2011)

Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes
por: Mendonça, Daiane Barros Dias, et al.
Publicado: (2019)

Nelfinavir is effective in inhibiting the multiplication and aspartic peptidase activity of Leishmania species, including strains obtained from HIV-positive patients
por: Santos, Lívia O., et al.
Publicado: (2013)

Effect of 3-Carene and the Micellar Formulation on Leishmania (Leishmania) amazonensis
por: Silva, Audrey Rouse Soares Tavares, et al.
Publicado: (2023)

Axenic Leishmania amazonensis Promastigotes Sense both the External and Internal Arginine Pool Distinctly Regulating the Two Transporter-Coding Genes
por: Castilho-Martins, Emerson A., et al.
Publicado: (2011)

Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole
por: Andrade-Neto, Valter Viana, et al.
Publicado: (2016)

Docking simulation between HIV peptidase inhibitors and Trypanosoma cruzi aspartyl peptidase
por: Castilho, Vanessa V. S., et al.
Publicado: (2018)

Carajurin Induces Apoptosis in Leishmania amazonensis Promastigotes through Reactive Oxygen Species Production and Mitochondrial Dysfunction
por: Silva-Silva, João Victor, et al.
Publicado: (2022)

Biological effects of trans, trans-farnesol in Leishmania amazonensis
por: Pinheiro, Liliane Sena, et al.
Publicado: (2023)

Imidazo[1,2-a]pyrimidine as a New Antileishmanial Pharmacophore against Leishmania amazonensis Promastigotes and Amastigotes
por: Kumar, Ravinder, et al.
Publicado: (2023)

DC-SIGN receptor is expressed by cells from cutaneous leishmaniasis lesions and differentially binds to Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis promastigotes
por: Mendes-Aguiar, Carolina de O, et al.
Publicado: (2023)

Recombinant Forms of Leishmania amazonensis Excreted/Secreted Promastigote Surface Antigen (PSA) Induce Protective Immune Responses in Dogs
por: Petitdidier, Elodie, et al.
Publicado: (2016)

Mapping Alterations Induced by Long-Term Axenic Cultivation of Leishmania amazonensis Promastigotes With a Multiplatform Metabolomic Fingerprint Approach
por: Crepaldi, Frederico, et al.
Publicado: (2019)

Proteome and morphological analysis show unexpected differences between promastigotes of Leishmania amazonensis PH8 and LV79 strains
por: Tano, Fabia Tomie, et al.
Publicado: (2022)

The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds
por: Oliveira, Simone S. C., et al.
Publicado: (2023)

Cinnamides Target Leishmania amazonensis Arginase Selectively
por: da Silva, Edson Roberto, et al.
Publicado: (2020)

Therapeutic Strategies against Leishmania and Trypanosoma
por: Santos, André L. S., et al.
Publicado: (2023)

Visceral leishmaniasis caused by Leishmania (Leishmania) amazonensis associated with Hodgkin’s lymphoma
por: Porto, Victor Bertolo Gomes, et al.
Publicado: (2022)

Sphingolipid Degradation in Leishmania (Leishmania) amazonensis
por: Pillai, Agiesh Balakrishna, et al.
Publicado: (2012)

Essential oils: in vitro activity against Leishmania amazonensis, cytotoxicity and chemical composition
por: Andrade, Milene Aparecida, et al.
Publicado: (2016)

Repositioning drug strategy against Trypanosoma cruzi: lessons learned from HIV aspartyl peptidase inhibitors
por: Sangenito, Leandro Stefano, et al.
Publicado: (2022)

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions
por: Petropolis, Debora B., et al.
Publicado: (2014)

Neutrophils Reduce the Parasite Burden in Leishmania (Leishmania) amazonensis-Infected Macrophages
por: Carmo, Érico Vinícius de Souza, et al.
Publicado: (2010)

Surface antigens of Leishmania donovani promastigotes
Publicado: (1983)

Increased Abundance of Proteins Involved in Resistance to Oxidative and Nitrosative Stress at the Last Stages of Growth and Development of Leishmania amazonensis Promastigotes Revealed by Proteome Analysis
por: Alcolea, Pedro J., et al.
Publicado: (2016)

Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy
por: Santos, L.O., et al.
Publicado: (2013)

The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite
por: Tschoeke, Diogo A, et al.
Publicado: (2014)

Endoplasmic Stress Affects the Coinfection of Leishmania Amazonensis and the Phlebovirus (Bunyaviridae) Icoaraci
por: dos Santos, José V., et al.
Publicado: (2022)

1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in Leishmania amazonensis Promastigote: An in Vitro Antileishmanial and in Silico Pharmacokinetic Study
por: Almeida-Souza, Fernando, et al.
Publicado: (2020)

Toxicity and Anti-promastigote Activity of Benzoxazinoid Analogs Against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) infantum
por: de Sousa, Gilberto, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_48pdhpsdnvdm3318p387heg5vb