Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their specific molecular targets in vivo. This is a particular p...

Descripción completa

Detalles Bibliográficos
Autores principales: Alcobia, Diana C., Ziegler, Alexandra I., Kondrashov, Alexander, Comeo, Eleonora, Mistry, Sarah, Kellam, Barrie, Chang, Aeson, Woolard, Jeanette, Hill, Stephen J., Sloan, Erica K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137713/
https://www.ncbi.nlm.nih.gov/pubmed/30240618
http://dx.doi.org/10.1016/j.isci.2018.08.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137713/
https://www.ncbi.nlm.nih.gov/pubmed/30240618
http://dx.doi.org/10.1016/j.isci.2018.08.006

Ejemplares similares