Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity

BACKGROUND: Lead (Pb), a heavy metal, and quinolinic acid (QA), a metabolite of the kynurenine pathway of tryptophan metabolism, are known neurotoxicants. Both Pb and QA impair spatial learning and memory. Pb activates astrocytes and microglia, which in turn induce the synthesis of QA. We hypothesiz...

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Detalles Bibliográficos
Autores principales: Rahman, Abdur, Rao, Muddanna S., Khan, Khalid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137743/
https://www.ncbi.nlm.nih.gov/pubmed/30217162
http://dx.doi.org/10.1186/s12974-018-1306-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137743/
https://www.ncbi.nlm.nih.gov/pubmed/30217162
http://dx.doi.org/10.1186/s12974-018-1306-2

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