ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair processes at stalled or converging replication forks. Recent...

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Detalles Bibliográficos
Autores principales: Mutreja, Karun, Krietsch, Jana, Hess, Jeannine, Ursich, Sebastian, Berti, Matteo, Roessler, Fabienne K., Zellweger, Ralph, Patra, Malay, Gasser, Gilles, Lopes, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137818/
https://www.ncbi.nlm.nih.gov/pubmed/30184498
http://dx.doi.org/10.1016/j.celrep.2018.08.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137818/
https://www.ncbi.nlm.nih.gov/pubmed/30184498
http://dx.doi.org/10.1016/j.celrep.2018.08.019

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