Abnormal folate metabolism causes age‐, sex‐ and parent‐of‐origin‐specific haematological defects in mice

KEY POINTS: Folate (folic acid) deficiency and mutations in folate‐related genes in humans result in megaloblastic anaemia. Folate metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis and the transmission of one‐carbon methyl groups for cellular...

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Detalles Bibliográficos
Autores principales: Padmanabhan, Nisha, Menelaou, Katerina, Gao, Jiali, Anderson, Alexander, Blake, Georgina E. T., Li, Tanya, Daw, B. Nuala, Watson, Erica D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Endocrine, nutrition and metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138292/
https://www.ncbi.nlm.nih.gov/pubmed/30024025
http://dx.doi.org/10.1113/JP276419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138292/
https://www.ncbi.nlm.nih.gov/pubmed/30024025
http://dx.doi.org/10.1113/JP276419

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