Epigenetic suppression of the anti-aging gene KLOTHO in human prostate cancer cell lines

KLOTHO was originally identified as an aging-suppressor gene that causes a human aging-like phenotype when tested in KLOTHO-deficient-mice. Recent evidence suggests that KLOTHO functions as a tumor suppressor by inhibiting Wnt signaling. KLOTHO gene silencing, including DNA methylation, has been obs...

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Detalles Bibliográficos
Autores principales: Seo, Minkyu, Kim, Min Su, Jang, Ara, Chung, Hyun Joo, Noh, Yoohun, Kim, Do-Hee, Lee, Jaehyouk, Ko, Kisung, Myung, Soon Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138301/
https://www.ncbi.nlm.nih.gov/pubmed/30460073
http://dx.doi.org/10.1080/19768354.2017.1336112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138301/
https://www.ncbi.nlm.nih.gov/pubmed/30460073
http://dx.doi.org/10.1080/19768354.2017.1336112

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