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Stimulation of transforming growth factor-beta-1 and contact with type I collagen cooperatively facilitate irreversible transdifferentiation in proximal tubular cells

BACKGROUND: By transdifferentiation, proximal tubular cells (PTC) have been considered as a source of interstitial myofibroblasts. We examined the combined effect of transforming growth factor-beta-1 (TGF-β1) stimulation and contact with type I collagen on PTC transdifferentiation. METHODS: Human ki...

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Detalles Bibliográficos
Autores principales:	Yen, Chieh-Li, Li, Yi-Jung, Wu, Hsin-Hsu, Weng, Cheng-Hao, Lee, Cheng-Chia, Chen, Yung-Chang, Chang, Ming-Yang, Yen, Tzung-Hai, Hsu, Hsiang-Hao, Hung, Cheng-Chieh, Yang, Chih-Wei, Tian, Ya-Chung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chang Gung University 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138427/ https://www.ncbi.nlm.nih.gov/pubmed/27105597 http://dx.doi.org/10.1016/j.bj.2015.08.004

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