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Development of sensitive ddPCR assays to reliably quantify the proviral DNA reservoir in all common circulating HIV subtypes and recombinant forms

INTRODUCTION: The latent reservoir is the main barrier on the road to HIV cure, and clinical approaches towards eradication are often evaluated by their effect on proviral DNA. To ensure inclusiveness and representativeness in HIV cure studies, proviral DNA quantification assays that are able to det...

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Detalles Bibliográficos
Autores principales: Bosman, Kobus J, Wensing, Annemarie MJ, Pijning, Aster E, van Snippenberg, Wilco J, van Ham, Petra M, de Jong, Dorien MC, Hoepelman, Andy IM, Nijhuis, Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138437/
https://www.ncbi.nlm.nih.gov/pubmed/30375818
http://dx.doi.org/10.1002/jia2.25185