A Novel 3-dimensional High Throughput Screening Approach Identifies Inducers of a Mutant KRAS Selective Lethal Phenotype

The RAS proteins are the most frequently mutated oncogenes in cancer, with highest frequency found in pancreatic, lung, and colon tumors. Moreover, the activity of RAS is required for the proliferation and/or survival of these tumor cells and thus represents a high-value target for therapeutic devel...

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Detalles Bibliográficos
Autores principales: Kota, Smitha, Hou, Shurong, Guerrant, William, Madoux, Franck, Troutman, Scott, Fernandez-Vega, Virneliz, Alekseeva, Nina, Madala, Neeharika, Scampavia, Louis, Kissil, Joseph, Spicer, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138545/
https://www.ncbi.nlm.nih.gov/pubmed/29743592
http://dx.doi.org/10.1038/s41388-018-0257-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138545/
https://www.ncbi.nlm.nih.gov/pubmed/29743592
http://dx.doi.org/10.1038/s41388-018-0257-5

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