Enhanced uptake of gH625 by blood brain barrier compared to liver in vivo: characterization of the mechanism by an in vitro model and implications for delivery

We have investigated the crossing of the blood brain barrier (BBB) by the peptide gH625 and compared to the uptake by liver in vivo. We clearly observed that in vivo administration of gH625 allows the crossing of the BBB, although part of the peptide is sequestered by the liver. Furthermore, we used...

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Detalles Bibliográficos
Autores principales: Falanga, Annarita, Iachetta, Giuseppina, Lombardi, Lucia, Perillo, Emiliana, Lombardi, Assunta, Morelli, Giancarlo, Valiante, Salvatore, Galdiero, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138628/
https://www.ncbi.nlm.nih.gov/pubmed/30218088
http://dx.doi.org/10.1038/s41598-018-32095-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138628/
https://www.ncbi.nlm.nih.gov/pubmed/30218088
http://dx.doi.org/10.1038/s41598-018-32095-w

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