A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a structural heart disease that causes dilatation of cardiac chambers and impairs cardiac contractility. The SCN5A gene encodes Na(v)1.5, the predominant cardiac sodium channel alpha subunit. SCN5A mutations have been identified in patients with arrhythmic disorders a...

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Detalles Bibliográficos
Autores principales: Moreau, Adrien, Gosselin-Badaroudine, Pascal, Mercier, Aurélie, Burger, Bettina, Keller, Dagmar I., Chahine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138662/
https://www.ncbi.nlm.nih.gov/pubmed/30218094
http://dx.doi.org/10.1038/s41598-018-31772-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138662/
https://www.ncbi.nlm.nih.gov/pubmed/30218094
http://dx.doi.org/10.1038/s41598-018-31772-0

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