HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of...

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Detalles Bibliográficos
Autores principales: Di Rita, Anthea, Peschiaroli, Angelo, D′Acunzo, Pasquale, Strobbe, Daniela, Hu, Zehan, Gruber, Jens, Nygaard, Mads, Lambrughi, Matteo, Melino, Gerry, Papaleo, Elena, Dengjel, Jörn, El Alaoui, Said, Campanella, Michelangelo, Dötsch, Volker, Rogov, Vladimir V., Strappazzon, Flavie, Cecconi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138665/
https://www.ncbi.nlm.nih.gov/pubmed/30217973
http://dx.doi.org/10.1038/s41467-018-05722-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138665/
https://www.ncbi.nlm.nih.gov/pubmed/30217973
http://dx.doi.org/10.1038/s41467-018-05722-3

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