Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

In mammalian cells, one-third of all polypeptides are transported into or across the ER membrane via the Sec61 channel. While the Sec61 complex facilitates translocation of all polypeptides with amino-terminal signal peptides (SP) or transmembrane helices, the Sec61-auxiliary translocon-associated p...

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Detalles Bibliográficos
Autores principales: Nguyen, Duy, Stutz, Regine, Schorr, Stefan, Lang, Sven, Pfeffer, Stefan, Freeze, Hudson H., Förster, Friedrich, Helms, Volkhard, Dudek, Johanna, Zimmermann, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138672/
https://www.ncbi.nlm.nih.gov/pubmed/30217974
http://dx.doi.org/10.1038/s41467-018-06188-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138672/
https://www.ncbi.nlm.nih.gov/pubmed/30217974
http://dx.doi.org/10.1038/s41467-018-06188-z

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