Cargando…

The m(6)A-methylase complex recruits TREX and regulates mRNA export

N(6)-methyladenosine (m(6)A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Recruitment of the TREX mRNA export comple...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lesbirel, Simon, Viphakone, Nicolas, Parker, Matthew, Parker, Jacob, Heath, Catherine, Sudbery, Ian, Wilson, Stuart A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138711/ https://www.ncbi.nlm.nih.gov/pubmed/30218090 http://dx.doi.org/10.1038/s41598-018-32310-8

Ejemplares similares

The m(6)A‑methylase complex and mRNA export()
por: Lesbirel, Simon, et al.
Publicado: (2019)

TREX exposes the RNA binding domain of Nxf1 to enable mRNA export
por: Viphakone, Nicolas, et al.
Publicado: (2012)

The role of TREX in gene expression and disease
por: Heath, Catherine G., et al.
Publicado: (2016)

Co-transcriptional Loading of RNA Export Factors Shapes the Human Transcriptome
por: Viphakone, Nicolas, et al.
Publicado: (2019)

Luzp4 defines a new mRNA export pathway in cancer cells
por: Viphakone, Nicolas, et al.
Publicado: (2015)

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway
por: Aksenova, Vasilisa, et al.
Publicado: (2020)

Recruitment of the Complete hTREX Complex Is Required for Kaposi's Sarcoma–Associated Herpesvirus Intronless mRNA Nuclear Export and Virus Replication
por: Boyne, James R., et al.
Publicado: (2008)

Mediator and TREX-2: Emerging links between transcription initiation and mRNA export
por: Schubert, Tobias, et al.
Publicado: (2016)

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export
por: Jani, Divyang, et al.
Publicado: (2014)

THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo
por: Mancini, Annalisa, et al.
Publicado: (2010)

Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export
por: Lim, Suji, et al.
Publicado: (2022)

Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA
por: Chi, Binkai, et al.
Publicado: (2013)

ORC interacts with THSC/TREX-2 and its subunits promote Nxf1 association with mRNP and mRNA export in Drosophila
por: Kopytova, Daria, et al.
Publicado: (2016)

The Proteins PDIP3 and ZC11A Associate with the Human TREX Complex in an ATP-Dependent Manner and Function in mRNA Export
por: Folco, Eric G., et al.
Publicado: (2012)

A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18
por: Chi, Binkai, et al.
Publicado: (2014)

Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
por: Bhat, Prasanna, et al.
Publicado: (2023)

UIF, a New mRNA Export Adaptor that Works Together with REF/ALY, Requires FACT for Recruitment to mRNA
por: Hautbergue, Guillaume M., et al.
Publicado: (2009)

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2
por: Dimitrova, Lyudmila, et al.
Publicado: (2015)

SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis
por: Yang, Yu, et al.
Publicado: (2017)

Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair
por: Evangelista, Federica M., et al.
Publicado: (2018)

The N(6)-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
por: Dorn, Lisa E., et al.
Publicado: (2019)

Nuclear export of plant pararetrovirus mRNAs involves the TREX complex, two viral proteins and the highly structured 5′ leader region
por: Kubina, Julie, et al.
Publicado: (2021)

The transcription and export complex THO/TREX contributes to transcription termination in plants
por: Khan, Ghazanfar Abbas, et al.
Publicado: (2020)

Mapping Interactions between mRNA Export Factors in Living Cells
por: Teng, I-Fang, et al.
Publicado: (2013)

SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block
por: Burke, James M., et al.
Publicado: (2021)

Molecular dissection of mRNA poly(A) tail length control in yeast
por: Viphakone, Nicolas, et al.
Publicado: (2008)

mRNA export: threading the needle
por: Gaouar, Ouassila, et al.
Publicado: (2013)

Nuclear mRNA Export and Aging
por: Park, Hyun-Sun, et al.
Publicado: (2022)

The Nuclear Pore Complex and mRNA Export in Cancer
por: Borden, Katherine L. B.
Publicado: (2020)

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex
por: Ellisdon, Andrew M., et al.
Publicado: (2012)

RNase L limits host and viral protein synthesis via inhibition of mRNA export
por: Burke, James M., et al.
Publicado: (2021)

Virus Infection and mRNA Nuclear Export
por: Guo, Jiayin, et al.
Publicado: (2023)

The Ccr4-Not Complex Interacts with the mRNA Export Machinery
por: Kerr, Shana C., et al.
Publicado: (2011)

mRNA recognition and packaging by the human transcription-export complex
por: Pacheco-Fiallos, Belén, et al.
Publicado: (2023)

Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts
por: Kramer, Susanne
Publicado: (2021)

An Interaction between KSHV ORF57 and UIF Provides mRNA-Adaptor Redundancy in Herpesvirus Intronless mRNA Export
por: Jackson, Brian R., et al.
Publicado: (2011)

mRNA adenosine methylase (MTA) deposits m(6)A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana
por: Bhat, Susheel Sagar, et al.
Publicado: (2020)

m(6)A Methylases Regulate Myoblast Proliferation, Apoptosis and Differentiation
por: Yang, Xinran, et al.
Publicado: (2022)

Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
por: Elbarbary, Reyad A., et al.
Publicado: (2016)

Defects in THO/TREX-2 function cause accumulation of novel cytoplasmic mRNP granules that can be cleared by autophagy
por: Eshleman, Nichole, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_d2rg2692cmns3fue5ppupjh43r