Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and subsequent pathology. We aimed to develop recombinant molecules with enhanced Fc receptor a...

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Detalles Bibliográficos
Autores principales: Rowley, Tania F., Peters, Shirley J., Aylott, Mike, Griffin, Robert, Davies, Nicola L., Healy, Louise J., Cutler, Rona M., Eddleston, Alison, Pither, Thomas L., Sopp, Joshua M., Zaccheo, Oliver, Fossati, Gianluca, Cain, Katharine, Ventom, Andrew M., Hailu, Hanna, Ward, Eleanor J., Sherington, John, Brennan, Frank R., Fallah-Arani, Farnaz, Humphreys, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138732/
https://www.ncbi.nlm.nih.gov/pubmed/30272022
http://dx.doi.org/10.1038/s42003-018-0149-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138732/
https://www.ncbi.nlm.nih.gov/pubmed/30272022
http://dx.doi.org/10.1038/s42003-018-0149-9

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