A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca(2+) permeability

A variety of de novo and inherited missense mutations associated with neurological disorders are found in the NMDA receptor M4 transmembrane helices, which are peripheral to the pore domain in eukaryotic ionotropic glutamate receptors. Subsets of these mutations affect receptor gating with dramatic...

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Detalles Bibliográficos
Autores principales: Amin, Johansen B., Leng, Xiaoling, Gochman, Aaron, Zhou, Huan-Xiang, Wollmuth, Lonnie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138751/
https://www.ncbi.nlm.nih.gov/pubmed/30217972
http://dx.doi.org/10.1038/s41467-018-06145-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138751/
https://www.ncbi.nlm.nih.gov/pubmed/30217972
http://dx.doi.org/10.1038/s41467-018-06145-w

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