Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, we focus on evi...

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Detalles Bibliográficos
Autores principales: Di Virgilio, Francesco, Giuliani, Anna Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2016
Materias:
Review Articles: Special Edition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138817/
https://www.ncbi.nlm.nih.gov/pubmed/27884379
http://dx.doi.org/10.1016/j.bj.2016.08.006
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author Di Virgilio, Francesco
Giuliani, Anna Lisa
author_facet Di Virgilio, Francesco
Giuliani, Anna Lisa
author_sort Di Virgilio, Francesco
collection PubMed
description Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, we focus on evidence supporting a possible role of the P2X7R in the pathogenesis of systemic lupus erythematosus (SLE).
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spelling pubmed-61388172018-09-27 Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus? Di Virgilio, Francesco Giuliani, Anna Lisa Biomed J Review Articles: Special Edition Purinergic signalling plays a crucial role in immunity and autoimmunity. Among purinergic receptors, the P2X7 receptor (P2X7R) has an undisputed role as it is expressed to high level by immune cells, triggers cytokine release and modulates immune cell differentiation. In this review, we focus on evidence supporting a possible role of the P2X7R in the pathogenesis of systemic lupus erythematosus (SLE). Chang Gung University 2016-10 2016-10-27 /pmc/articles/PMC6138817/ /pubmed/27884379 http://dx.doi.org/10.1016/j.bj.2016.08.006 Text en © 2016 Chang Gung University. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Articles: Special Edition
Di Virgilio, Francesco
Giuliani, Anna Lisa
Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
title Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
title_full Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
title_fullStr Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
title_full_unstemmed Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
title_short Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
title_sort purinergic signalling in autoimmunity: a role for the p2x7r in systemic lupus erythematosus?
topic Review Articles: Special Edition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138817/
https://www.ncbi.nlm.nih.gov/pubmed/27884379
http://dx.doi.org/10.1016/j.bj.2016.08.006
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