Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

BACKGROUND: Cancer susceptibility germline variants generally require somatic alteration of the remaining allele to drive oncogenesis and, in some cases, tumor mutational profiles. Whether combined germline and somatic bi-allelic alterations are universally required for germline variation to influen...

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Detalles Bibliográficos
Autores principales: Buckley, Alexandra R., Ideker, Trey, Carter, Hannah, Harismendy, Olivier, Schork, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138910/
https://www.ncbi.nlm.nih.gov/pubmed/30217226
http://dx.doi.org/10.1186/s13073-018-0579-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138910/
https://www.ncbi.nlm.nih.gov/pubmed/30217226
http://dx.doi.org/10.1186/s13073-018-0579-5

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