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Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

BACKGROUND: Cancer susceptibility germline variants generally require somatic alteration of the remaining allele to drive oncogenesis and, in some cases, tumor mutational profiles. Whether combined germline and somatic bi-allelic alterations are universally required for germline variation to influen...

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Detalles Bibliográficos
Autores principales:	Buckley, Alexandra R., Ideker, Trey, Carter, Hannah, Harismendy, Olivier, Schork, Nicholas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138910/ https://www.ncbi.nlm.nih.gov/pubmed/30217226 http://dx.doi.org/10.1186/s13073-018-0579-5

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