Cargando…

LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling

BACKGROUND: In this research, we aimed to investigate the biological functions of LIM domain only 3 (LMO3) in hepatocellular carcinoma (HCC) and uncover the underlying molecular mechanism in it. METHODS: HCC tissue microarray (n = 180) was used to analyze the correlation between LMO3 expression and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Yang, Hou, Tianlu, Ping, Jian, Chen, Tianyang, Yin, Baobing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139164/ https://www.ncbi.nlm.nih.gov/pubmed/30219064 http://dx.doi.org/10.1186/s13046-018-0903-3

Ejemplares similares

PRPH2 Activates Hippo Signalling and Suppresses the Invasion and Anoikis Inhibition of Laryngeal Cancer
por: Dong, KaiFeng, et al.
Publicado: (2019)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma
por: Guo, Chengyong, et al.
Publicado: (2019)

HRC promotes anoikis resistance and metastasis by suppressing endoplasmic reticulum stress in hepatocellular carcinoma
por: Xia, Suhong, et al.
Publicado: (2021)

miR-103 promotes the metastasis and EMT of hepatocellular carcinoma by directly inhibiting LATS2
por: Han, Li-Li, et al.
Publicado: (2018)

TNFAIP8 interacts with LATS1 and promotes aggressiveness through regulation of Hippo pathway in hepatocellular carcinoma
por: Dong, Qianze, et al.
Publicado: (2017)

miR-424-5p Promotes Anoikis Resistance and Lung Metastasis by Inactivating Hippo Signaling in Thyroid Cancer
por: Liu, Xiaoli, et al.
Publicado: (2019)

Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling
por: An, Yang, et al.
Publicado: (2013)

POPX2 is a novel LATS phosphatase that regulates the Hippo pathway
por: Rahmat, Muhammad Bakhait, et al.
Publicado: (2019)

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2
por: Park, Gun-Soo, et al.
Publicado: (2016)

LATS1 suppresses proliferation and invasion of cervical cancer
por: Deng, Jihong, et al.
Publicado: (2017)

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis
por: Zinatizadeh, Mohammad Reza, et al.
Publicado: (2019)

Interaction of S100A1 with LATS1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma
por: Guo, Qingping, et al.
Publicado: (2018)

Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis resistance of circulating tumor cells
por: Sun, Bin, et al.
Publicado: (2017)

Correction: POPX2 is a novel LATS phosphatase that regulates the Hippo pathway
por: Rahmat, Muhammad Bakhait, et al.
Publicado: (2019)

Effects of Quinacrine on Expression of Hippo signaling Pathway Components (LATS1, LATS2, and YAP) in Human Breast Cancer Stem Cells
por: Darbankhales, Soroush, et al.
Publicado: (2020)

Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells
por: Lee, Jie-Jen, et al.
Publicado: (2021)

Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
por: Hergovich, Alexander
Publicado: (2013)

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
por: Azad, T., et al.
Publicado: (2018)

O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity
por: Kim, Eunah, et al.
Publicado: (2020)

Biochemical Feature of LMO2 Interactome and LMO2 Function Prospect
por: Wang, Wenhao, et al.
Publicado: (2020)

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
por: Fanfone, Deborah, et al.
Publicado: (2022)

Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
por: Kim, Yong-Nyun, et al.
Publicado: (2012)

LMO7 as an Unrecognized Factor Promoting Pancreatic Cancer Progression and Metastasis
por: Liu, Xinjian, et al.
Publicado: (2021)

Inhibition of p600 Expression Suppresses Both Invasiveness and Anoikis Resistance of Gastric Cancer
por: Sakai, Hiroshi, et al.
Publicado: (2011)

Oncogenic PAX6 elicits CDK4/6 inhibitor resistance by epigenetically inactivating the LATS2‐Hippo signaling pathway
por: Zhang, Yi, et al.
Publicado: (2021)

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling
por: Ni, Lisheng, et al.
Publicado: (2015)

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner
por: García-Gutiérrez, Lucía, et al.
Publicado: (2022)

LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling
por: Liu, Ye, et al.
Publicado: (2016)

Anoikis-Associated Lung Cancer Metastasis: Mechanisms and Therapies
por: Wang, Jing, et al.
Publicado: (2022)

Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis
por: Neuendorf, Hannah M., et al.
Publicado: (2023)

PMEPA1 isoform a drives progression of glioblastoma by promoting protein degradation of the Hippo pathway kinase LATS1
por: Ji, Jianxiong, et al.
Publicado: (2019)

Identification of Anoikis-Related Subgroups and Prognosis Model in Liver Hepatocellular Carcinoma
por: Chen, Yutong, et al.
Publicado: (2023)

KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling
por: Tong, Rongliang, et al.
Publicado: (2017)

miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis
por: Liu, Yankun, et al.
Publicado: (2017)

Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
por: Ma, Biao, et al.
Publicado: (2016)

DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins
por: Nguyen, Hung Thanh, et al.
Publicado: (2017)

miR-363 confers taxane resistance in ovarian cancer by targeting the Hippo pathway member, LATS2
por: Mohamed, Zeinab, et al.
Publicado: (2018)

Novel insights into the regulation of LATS2 kinase in prehierarchical follicle development via the Hippo pathway in hen ovary
por: Sun, Xue, et al.
Publicado: (2021)

Protocols for measuring phosphorylation, subcellular localization, and kinase activity of Hippo pathway components YAP and LATS in cultured cells
por: Luo, Min, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3c4kjes0cpf678v3fbbd58e9ru